Scoping Review · Evidence Visualisation

B-HOT Evidence Dashboard

An interactive visualisation dashboard of the Banff Human Organ Transplant (B-HOT) panel literature.

31Included studies
11Core studies
4Organs covered
2020–2026Publication window
4Visualisations
1

Evidence Map by Year, Organ & Role in Review

Landscape overview

Description

Each bubble represents one included study, positioned by publication year (x-axis) and organ (y-axis). Bubble colour encodes the study's role in the review: dark green = Core, medium green = Support citation, pale green = Discussion only. Overlapping bubbles are spread vertically for clarity.

2

Role in Review — Core · Supporting Citation · Discussion Only

Evidence architecture

Description

A stacked horizontal bar chart showing how the 31 included studies distribute across the six primary manuscript sections. Each bar is subdivided by role in review, giving an immediate map of the evidence architecture. The legend order and colour scheme (dark/medium/pale green) match the evidence map.

SectionCoreSupportDisc.n
Foundational / Rationale2002
Core kidney readiness7209
Cross-organ / cross-context1225
Bridge to next-gen0202
Challenges / Limitations1326
Background / Commentary0055
3

Core Readiness Studies & Sample Size

Statistical weight

Description

A lollipop plot of all 11 Core studies, sorted chronologically (newest first). The x-axis shows the primary sample size (N biopsies analyzed with B-HOT), with the exact number labelled next to each dot. Dot colour encodes organ: blue = Kidney, orange = Heart, pink = Uterus.

StudyOrganN
Giarraputo 2026Heart671
Zielinski 2025Kidney950
Callemeyn 2025Kidney146
Eder 2025Kidney25
Broecker 2025Uterus99
Zhang 2024Kidney1,395
Buxeda 2024Kidney92
Cristoferi 2024Kidney36
Beadle 2023Kidney349
Smith 2023Kidney326
Varol 2023Kidney96
Rosales 2022Kidney326
4

B-HOT Evidence Landscape

Evidence maturity & translation stage

Description

Each cell shows the count of included studies at the intersection of a transplant organ context (rows) and a study characteristic tag (columns). Colour intensity scales with count — darker green = more studies. Hover over any cell to see the individual studies it contains.

Column tags: BHOT — study runs the B-HOT/BHOTX NanoString assay directly; COMP — B-HOT genes used as reference in another assay; RET — retrospective archival cohort; MC — multicenter design supporting transportability; CLS — classifier or clinical implementation work; MECH — mechanistic immunobiology; MULTI — multimodal profiling (mIF, spatial, IHC).